Methylation of the GHSR and NMUR1 promoters correlated positively with recurrence in oropharyngeal cancer patients, both individually (OR, 3.853; 95% CI, 1.510–9.832; P = 0.005 and OR, 2.872; 95% CI, 1.172–7.037; P = 0.036, respectively) and together (OR, 3.272; 95% CI, 1.216–8.801; P = 0.019) (Fig. 4). The gene discussed is GHSR; the disease is oropharynx cancer.