RAD51 and B-cell chronic lymphocytic leukemia: To this extent, we first used the pan-specific PI3K inhibitior copanlisib in the CRISPR/Cas9-generated cells, showing that PI3K inhibition also reduced the recruitment of RAD51 to DSB lesions (Supplementary Fig. S7c), presenting synergistic effects with olaparib in stimulated primary CLL cells (Fig. 5b, left panel) and CLL cell lines (Supplementary Fig. S7d).