In addition, HG3-del(11q) ATMKO cells exhibited more DNA damage upon olaparib + ibrutinib and the triple combination than HG3WT cells, providing further evidence of the selective hypersensitivity of del(11q)/ATMKO CLL cells to PARP inhibitors in combination with ibrutinib. The gene discussed is PKD1P3; the disease is B-cell chronic lymphocytic leukemia.