Among the 10 hub DMGs revealed, six (STAT3, PTPN6, SYK, STAT5B, XPO1, and ABL1) had known CLL relevance (blue tint), whereas the remaining four (UBC, GRB2, CREBBP, and GAB2) did not. This evidence concerns the gene GRB2 and B-cell chronic lymphocytic leukemia.