Among the 10 hub DMGs revealed, six (STAT3, PTPN6, SYK, STAT5B, XPO1, and ABL1) had known CLL relevance (blue tint), whereas the remaining four (UBC, GRB2, CREBBP, and GAB2) did not. Here, XPO1 is linked to B-cell chronic lymphocytic leukemia.