TGFB2 and cancer: In an attempt to establish a link between EMT and LD accumulation, both being promoted by acidosis-driven TGF-β2 signaling, we could document that silencing ZEB1 blocked EMT in 6.5/cancer cells (Supplementary Fig. 5k) but also reduced the formation of LD under acidosis (Fig. 5i and Supplementary Fig. 5l).