PNPLA2 and cancer: To more directly prove that fatty acid mobilization from LD accounted for the increased invasive potential of 6.5/cancer cells, we inhibited ATGL with atglistatin and documented a similar reduction in invasiveness (Fig. 2j); this experiment was carried out in the presence of serum further confirming that exogenous FA could not rescue the invasive capacity of lipase-inhibited 6.5/cancer cells.