We first confirmed that after adaptation to pH 6.5 (Supplementary Fig. 6a), HT-29 cancer cells accumulated neutral lipids within lipid droplets (Supplementary Fig. 6b–f) and exhibited a higher invasiveness potential (Supplementary Fig. 6g) together with an increased TGF-β2 (but not TGF-β1) signaling (Supplementary Fig. 6h–n). The gene discussed is TGFB1; the disease is cancer.