HMGCR and cancer: Inhibitors of HMG-CoA reductase (simvastatin) and ACAT (avasimibe), as well as the use of lipoprotein-deficient serum, failed to influence LD formation (Supplementary Fig. 1l), in agreement with the lack of differences in the extent of CE between native and acidosis-adapted cancer cells (Fig. 1g and Supplementary Fig. 1g).