TGFB2 and cancer: Importantly, we documented the druggability of this intrinsic alteration of the cancer cell phenotype with SB431542, a potent and specific inhibitor of TGF-β superfamily type 1 receptor, and AP12009/Trabedersen, a FDA- and EMEA-approved orphan anticancer drug, active as a TGF-β2-specific antisense oligodeoxynucleotide.