Importantly, inhibition of TGF-β2 signaling led to a significant reduction in the invasion of acidosis-adapted cancer cells through Matrigel (Fig. 3j and Supplementary Fig. 3m) and prevented LD formation in 6.5/cancer cells (Fig. 3k), an effect paralleled by a reduction in the amounts of neutral lipids (Supplementary Fig. 3n). This evidence concerns the gene TGFB2 and cancer.