DDHD2 and neoplasm: Together with our data on the supportive role of LD in anoikis resistance and local cancer cell invasion, these findings offer a rationale for the development of drugs inhibiting the mobilization of FA (e.g., atglistatin) to reduce metastatic spreading by preventing the use by cancer cells of the energy stored in preformed LD; the blockade of triglyceride lipase is all the more relevant as it can also interfere with (tumor-induced) release of FA from adipocytes to fuel cancer cell LD64.