PNPLA2 and cancer: Instead of removing LD from acidosis-adapted cancer cells, we next inhibited FA release from LD by blocking the activity of adipose triglyceride lipase (ATGL) with atglistatin and found that this treatment similarly accelerated cell death in 6.5/cancer cells cultured in a low serum-containing medium (Fig. 2c and Supplementary Fig. 2d).