SREBF1 and neoplasm: In agreement with our findings that PPARγ promoted expression of SREBP1 and synthesis of cholesterol in mouse iNKT cells (Fig. 4a-d, f, g), reduced SREBP1 (Fig. 5b) and cholesterol levels (Fig. 5c) were detected in human tumor-infiltrating iNKT cells, and the level of SREBP1 and cholesterol were positively correlated with the level of PPARγ in cells from tumors and para-carcinoma tissues (Fig. 5d, e).