To delineate the CREs that could be actively involved in the transcriptional regulation of FOXA1, we annotated the DHS with available ChIP-seq data for histone modifications and TFs conducted in LNCaP, 22Rv1, VCaP prostate cancer cell lines and primary prostate tumors (Fig. 2b)18,38. This evidence concerns the gene FOXA1 and prostate cancer.