RNAi-mediated essentiality screens compiled in DEPMAP show that FOXA1 lies in the 94th percentile across six of the eight available prostate cancer cell lines: 22Rv1, LNCaP, MDA PCa 2B, NCI-H660, PC3, and VCaP cells (Fig. 1b, c). This evidence concerns the gene FOXA1 and Familial prostate cancer.