Tumor SK1 downregulation increased the proportion of IFN-γ-producing CD8 + TILs (Fig. 3c) and CD107a + and granzyme + CD8 T cells (Supplementary Fig. 1c), as well as the expression of PD-1, CTLA-4, and TIM-3 on CD8 + TILs (Fig. 3d, e) that likely reflect an accumulation of activated CD8 + T cells at day 11. The gene discussed is HAVCR2; the disease is neoplasm.