TGFB1 and neoplasm: To understand how tumor SK1 expression and Treg infiltration were related, the expression of immunosuppressive cytokines (TGF-β and IL-10) and chemokines (CCL17 and CCL22) that support Treg recruitment23,24, was evaluated in tumors from mice injected with shCtrl or shSK1(1) Yumm cells.