To investigate the function of B7-H3 in CRC angiogenesis, three non-overlapping siRNAs targeting B7-H3 (B7-H3 siRNA-1, B7-H3 siRNA-2, and B7-H3 siRNA-3) were used to knockdown the expression of B7-H3 in CRC cells (Supplementary Fig. S2a). The gene discussed is CD276; the disease is colorectal carcinoma.