Although B7-H3 knockdown or overexpression had no significant effect on tumor size or tumor weight (Supplementary Fig. S9a-f), knockdown of B7-H3 in HCT116 cells significantly decreased the MVD and inhibited VEGFA expression in Matrigel plug tumors compared with the control conditions, while overexpression of B7-H3 showed the opposite results (Fig. 6a–d and Supplementary Fig. S9g, h). Here, VEGFA is linked to neoplasm.