FOXO3 and diabetes mellitus: Another significant result was observed in aged PASK-deficient mice in relation to the expression of FoxO3A. The FoxO3a transcription factor has been considered a key mediator in the pathways involved in longevity, as it controls the expression of various antioxidant enzymes [53], preventing the development of various pathologies such as diabetes, cancer, and accelerated aging [54, 55].