AKT1 and cancer: Among these signaling pathways, we focused on the signaling pathways involved in IL-6 and found that these miRNAs were widely involved in the regulation of IL-6-related signaling pathways, including pathways in cancers, the PI3K-Akt signaling pathway, cytokine-cytokine receptor interaction, and the Toll-like receptor signaling pathway (Fig. 2e).