To better understand the contribution of these GBM cell-states within our Q-Cell resource, we firstly analysed 257 unique genes, separating tumours into six metamodules (MES1-, MES2-, NPC1-, NPC2-, OPC-, and AC-like) as per Suva and colleagues [9] encompassing each of the identified four cell-states. The gene discussed is NPC1; the disease is glioblastoma.