SIRT1 and B-cell non-Hodgkin lymphoma: We previously reported a dual SIRT1/2 inhibitor called cambinol 1 (in vitro IC50 54 and 46 μM respectively) [39] that sensitized cells to paclitaxel and etoposide and, was cytotoxic as a single agent against B-cell lymphoma cell lines in vitro and xenograft models in vivo.