Indeed, Hein et al. has shown that treatment of mice with acute myeloid leukaemia (AML) driven by the MLL/ENL fusion protein, reduces the number of myeloid blasts and increases the number of neutrophils in the bone marrow [82] suggesting that reducing Pol I transcription can directly affect haematopoietic differentiation. Here, MLLT1 is linked to acute myeloid leukemia.