C3 and hemolytic-uremic syndrome: Lastly, mice lacking the lectin-like domain of thrombomodulin, an endothelial glycoprotein with anticoagulant, anti-inflammatory, and cytoprotective properties, show higher glomerular C3 deposits and a higher mortality after intraperitoneal injection of Stx2 + LPS [193], and a deficiency of this protein has been implied in rare cases of atypical HUS [194].