In the present study, we constructed a bivalent antibody from humanized 528 (h528) Fv with affinity for the epidermal growth factor receptor (EGFR) frequently overexpressed on cancer cells [28], and a bispecific antibody from the h528 Fv and the agonistic humanized OKT3 (hOKT3) Fv that recruits CD3 receptors on T cells [29]. This evidence concerns the gene EGFR and cancer.