KLF15 and heart failure: Given the expression or activity of mitochondrial BCAA catabolic enzymes, such as the branched-chain α-keto acid dehydrogenase (BCKDH) complex, in the cardiac tissue is reduced in Klf15-null mice and heart failure [41,42], we investigated the BCKDH protein transcript, in addition to the BCKDH phosphorylation in the DOX-treated animals.