The results of our transcriptome are in accordance with the previous study of our research group that highlighted the therapeutic effects of TGF-β present in EVs derived from human Periodontal Ligament Stem Cells (hPDLSCs), in Experimental Autoimmune Encephalomyelitis (EAE), a mouse model of multiple sclerosis. Here, TGFB1 is linked to experimental autoimmune encephalomyelitis.