AD is a Central Nervous System (CNS) disorder leading to neurodegeneration [3] which is linked to abnormal amyloid-β (Aβ) metabolism [4], Tau (tubulin-associated unit) hyperphosphorylation [5,6], oxidative stress [7,8], reactive glial [9], microglial changes [10], and other pathological abnormalities [3]. This evidence concerns the gene MAPT and Alzheimer disease.