Current AD models include cytokine overexpression (e.g., IL-4 [216] and IL-31), genetic mutations leading to dysfunctional protein expression (e.g., Filaggrinft/flaky tail mice), NC/Nga model [76,217], PAR2 overexpression and house dust mite (HDM) application [215] and Aspergillus fumigatus-induced AD [200,218]. This evidence concerns the gene IL4 and Alzheimer disease.