Here, in an attempt to identify the regulatory networks of TUSC2-induced apoptosis in thyroid cancer cells, we used the Proteome Profiler Human Apoptosis Array (R&D Systems), and we found an increase in SMAC/DIABLO and CYTOCHROME C proteins in cells transfected with TUSC2 in response to apoptotic stimuli. This evidence concerns the gene TUSC2 and thyroid cancer.