DCX and Alzheimer disease: The number of DCX+ cells in 3xTg-AD mice significantly decreased as compared with that in wild-type mice, and LPS injection also decreased the number of synaptic puncta in the dendrites of DCX+ cells of 3xTG-AD mice, indicating that a single systemic inflammatory event also produces a long-term impairment on the formation of synaptic specializations in new born neurons of AD transgenic animal models.