CSF2 and bacterial infectious disease: One of these models, named MISTRG (BRG-CSF1h/hIL-3/CSF-2h/hSirpatg TPOh/h RAG2−/− IL2Rγ −/−), combines the knock-in of human thrombopoietin, IL-3, GM-CSF and M-CSF, and displays enhanced innate immunity against viral and bacterial infection in comparison to NSG mice [14].