Microglia release chemoattractants (monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1) when associated with glioma cells promoting further microglial/monocyte recruitment from the peripheral blood and, in combination with the cytokine milieu (IL-10, TGF-β and IL-6), promote further immunosuppression [36,41]. Here, TGFB1 is linked to central nervous system cancer.