In support of an important role of Tregs in glioma is an immunohistochemistry study comprising 62 patients, whose tumours were stained for FoxP3 and CD8 and found Treg accumulation at the tumour site was associated with poorer prognosis, while CD8+ tumour infiltrating lymphocytes (TILs) were not associated with increased survival [74]. Here, CD8A is linked to central nervous system cancer.