Indeed AactCDT induced secretion of IL-6 from resident fibroblasts [110], CjejCDT and infection with H. hepaticus expressing a functional genotoxin elicited IL8 secretion or mRNA production from the human embryo intestinal INT407 cells, as well as several colorectal-derived cell lines (T84, CaCo-2, HCA-7) 72 h post-treatment [111,112,113]. This evidence concerns the gene IL6 and infection.