The genotoxic activity of pks positive E. coli promotes acquisition of carcinogenic traits (genomic instability, enhanced mutation frequency, anchorage independent growth) in vitro [45], enhances tumor formation in germ free IL10 deficient mice treated with the pre-carcinogen azoxymethane (AOM) [37], impairs the intestinal homeostasis and consequently alters oral tolerance in rats upon neonatal colonization [46,47]. The gene discussed is IL10; the disease is neoplasm.