Interesting results were also obtained using orthotopic xenografts and a syngeneic mouse model with genetically color-coded macrophages (Ccr2RFP) and microglia (Cx3cr1GFP), in which microglia were found to effectively phagocytose tumour cells in response to anti-CD47 blockade with a reduced inflammatory signature, making them a promising target for clinical applications [55]. This evidence concerns the gene CD47 and neoplasm.