TMEM97 and neuroblastoma: Firstly, it was reported that incubation of human neuroblastoma SK-N-SH cells with the σ2R ligands like CB-64D, CB-64L, JL-II-147, BD737, LR172, BD1008, haloperidol, reduced-haloperidol, and ibogaine evoked a rise in cytosolic Ca2+ concentration in the absence and presence of extracellular Ca2+.