Even though IL-23p19−/−, IL-17RA−/− and IL-22−/− mice intravaginally inoculated with Candida suggested little-to-no evidence of Th17 cytokines being primary effectors during acute inflammation [114], the role of IL-22 has been long investigated recently for its ability to provide antifungal resistance during infection at the mucosal sites by preventing epithelial cell damage [115]. Here, IL22 is linked to infection.