CFTR and cystic fibrosis: Very recently, amino acids inserted at UGA, UAG, and UAA have been identified during readthrough mediated by non-aminoglycoside PTC124 in both yeast and human cells and by aminoglycoside G418 (geneticin) in human cells harboring reporters expressing mutated forms of CFTR outlining CF genetic disease (see below) [41,42,43].