GLP1R and chronic obstructive pulmonary disease: Krizhanovskii et al showed increased GLP1 in plasma of patients with dilatation of the ascending aorta, which could imply a decreased DPP-4 activity, and other studies have found a decreased DPP-4 activity in the plasma of patients with chronic obstructive pulmonary disease, a disease that has been linked to AAA rupture [40–42].