Only a few studies report on the role of DNA methylation in liposarcomas, but mostly focus on one specific DNA region in more aggressive liposarcomas subtypes.[25, 26] Some studies report a link between DNA methylation and microRNAs, for example methylation-induced silencing of miR-193b in dedifferentiated liposarcoma but not in WDLPS[27] and low expression of miR-193b, due to downregulation by promoter methylation, resulting at least partly from an increased expression of DNA methyltransferase-1.[28]. Here, DNMT1 is linked to liposarcoma.