This also raises the question whether the massive dermal MAC increase seen e.g. in lepromatous leprosy, leishmaniasis, granuloma annulare, and tattoo-associated granulomata [59,60] results not only from extravasating MOs, but also from the excessive local MAC maturation from resident, intracutaneous (CD34+)progenitor cells. The gene discussed is CD34; the disease is lepromatous leprosy.