Additional studies on potential drug–drug interactions in the context of ivermectin MDA for malaria vector control may need to be assessed as several antiretrovirals and tuberculosis (TB) drugs share the same metabolic pathway (p450 CYP) with ivermectin,57 which could lead to 1) unexpected higher levels of ivermectin or other commonly used drugs, such as antiretrovirals or anti-TB drugs, potentially causing toxicity or 2) lower levels of ivermectin, antiretrovirals, or anti-TB drugs, thus reducing efficacy. The gene discussed is PPIG; the disease is tuberculosis.