However, immune‐related adverse events (irAEs) induced by PD‐1/PD‐L1 inhibitors may require treatment with immunosuppressive agents, which could cause opportunistic infections.2, 3 In addition, there have been several reports describing reactivation of latent/chronic infections during immunotherapy without irAEs or having received immunosuppressants.4 Here, CD274 is linked to Opportunistic infection.