Mouse models of Lewis lung carcinoma have shown that Tregs inhibit natural killer (NK) cell‐mediated cytotoxicity in a TGF‐β‐dependent manner, and Treg depletion can enhance the anti‐tumor activity of NK cells.22 To further explore the mechanism by which GRP94 promotes the proliferation of lung AD cells, we evaluated the effect of GRP94 depletion on the TGF‐β signaling pathway. The gene discussed is HSP90B1; the disease is neoplasm.