EZH2 and thyroid gland carcinoma: They further demonstrated that knockdown of the H3K27‐specific methyltransferase EZH2 attenuated the H3K27me3‐mediated effects in vitro and in vivo.12 In addition, H3K27me3 overexpression is associated with aggressiveness and dedifferentiation of thyroid cancer.14 Furthermore, Hou and colleagues have elucidated that BRAFV600E regulates the expression of Ezh2, Suz12 and Jarid2 by c‐Myc, resulting in changes in H3K27me3 and subsequent epigenetic silencing.