Luan et al. reported that MDM2 T309 G polymorphism may contribute to NSCLC susceptibility, especially in the Asian population and women.18 Li et al. found that the GG genotype of MDM2 SNP309 was significantly associated with an increased endometrial cancer risk by the meta‐analysis.19 In our meta‐analysis, we also confirmed the G allele could increase the esophageal cancer susceptibility, which was in accordance with previous publications. This evidence concerns the gene MDM2 and non-small cell lung carcinoma.