Moreover, except for in cancer cells, we also found that USP14 regulates the progression of cardiac hypertrophy via promoting GSK‐3β phosphorylation and USP14 mediates LPS‐induced inflammation by activating ERK1/2 and NF‐κB pathways.22, 43 However, the function of USP14 in the development of atherosclerosis remains unknown. This evidence concerns the gene USP14 and cardiac hypertrophy.