It is reported that CD36 is a membrane protein and blocking CD36 inhibits lipid uptake and the development of atherosclerosis.30 In addition, CD36 is degraded via ubiquitin‐proteasome system (UPS).31 Hence, we speculated that deubiquitinase USP14 induced the down‐regulation of CD36 protein by promoting its degradation. This evidence concerns the gene USP14 and atherosclerosis.