SHH and Mobius syndrome: Integration of molecular data provided by advanced genomics started an exciting refinement of MB classifications [6]: the current consensus agrees upon four distinct molecular subgroups, wingless-activated (WNT-MB), sonic-hedgehog-activated (SHH-MB), and Group 3 and Group 4 MBs [7], each characterized by distinct variety of genetic alterations, transcriptional/methylation profiles, and clinical outcomes [2, 8–10].