BRAF and melanoma: Examples include the variable threshold of positivity for the expression of the HER2 receptor in gastric adenocarcinoma [10], progesterone and estrogen receptors in breast tumors [11], the EML4-ALK translocation in lung adenocarcinoma [12], B-RAF mutations in melanoma, and the 1p/19q allelic loss in oligodendrogliomas [13, 14].