PGRMC1 and cancer: Considering the cancer cells have the ability to rapidly proliferate by boosting conventional metabolic pathways for the synthesis of total biomass (proteins, lipids, and nucleic acids), and the maintenance of redox balance (DeBerardinis and Chandel, 2016; Renner et al., 2017), our present evidence of a strong correlation between up-regulation of PGRMC1 expression and activation of multiple metabolism pathways reveal its essential function for the survival and growth of malignant cells.