Furthermore, our data demonstrate that PGRMC1 over-expressed in lung squamous cell carcinoma, kidney renal clear cell carcinoma, esophageal carcinoma and skin cutaneous melanoma, and plays an unfavorable prognosis role in head and neck cancer, breast cancer, acute myelocytic leukemia, and sarcoma. This evidence concerns the gene PGRMC1 and squamous cell lung carcinoma.