As shown in Figure 3A, based on the TCGA database, the expression value of PGRMC1 in lung squamous cell carcinoma, kidney renal clear cell carcinoma, esophageal carcinoma was dramatically higher than matched normal samples, and the expression value in metastasis samples of skin cutaneous melanoma is significantly higher than primary tumor samples (Figure 3B). This evidence concerns the gene PGRMC1 and squamous cell lung carcinoma.