As shown in Figure 3A, based on the TCGA database, the expression value of PGRMC1 in lung squamous cell carcinoma, kidney renal clear cell carcinoma, esophageal carcinoma was dramatically higher than matched normal samples, and the expression value in metastasis samples of skin cutaneous melanoma is significantly higher than primary tumor samples (Figure 3B). The gene discussed is PGRMC1; the disease is carcinoma of esophagus.