As many studies reported that HNSC with concurrent mutation of multiple PI3K pathway genes were advanced (stage IV), implicating concerted PI3K pathway aberrations in HNSC progression (Qiu et al., 2006; Lui et al., 2013), these data revealed the positive correlation between PGRMC1 over-expression and PIK3CA genomic alterations, known for its association of cancer progression and metastasis, which provided further support for the oncogenic role of PGRMC1 and the potential interaction with PIK3CA. Here, PIK3CA is linked to cancer.