In addition, taurine increased the expression levels of BMP-2, Wnt3a, SMAD1/5/8, RUNX2, and COL-1 in the in vivo osteoporosis model and stimulated the p-Akt, p-p38, p-JNK, and p-ERK signaling pathways. The gene discussed is RUNX2; the disease is osteoporosis.