The detrimental effects of HFD were potentiated in Sirt2−/−; p53−/− mice after analyzing both overall survival (Sirt2−/−; p53−/−: HFD vs. ctrl p < 0.0001) and tumor incidence (Sirt2−/−; p53−/−: HFD vs. ctrl p < 0.0001) suggesting that SIRT2 exhibits tumor suppressive properties in this context as well (Figures 4A,B). The gene discussed is TP53; the disease is neoplasm.