Accordingly, both p53+/− and p53−/− mice fed on a HFD exhibited a significant decrease in overall survival (p53+/−: HFD vs. ctrl p < 0.0001 / p53−/−: HFD vs. ctrl p = 0.03) and median survival (p53+/−: 446 days ctrl vs. 293 days HFD / p53−/−:179 days ctrl vs. 139.5 days HFD) which was further associated with increased tumor incidence (p53+/−: HFD vs. ctrl p < 0.0001, HR = 4.01 / p53−/−: HFD vs. ctrl p = 0.03, HR = 1.58), as compared to the control diet group (Figure 4 and Supplementary Table 1). Here, TP53 is linked to neoplasm.