SIRT3 and neoplasm: On the contrary, the beneficial effect from CR was maintained in the Sirt3−/−; p53−/− mice as evidenced by the increased survival (Sirt3−/−; p53−/−: CR vs. ctrl p = 0.05) and delay in tumor development (Sirt3−/−; p53−/−: CR vs. ctrl p = 0.001) (Figures 3A,B).