TP53 and neoplasm: In both the Sirt2−/−; p53−/− (Figures 2A,B) and Sirt2−/−; p53+/− (Figures 2C,D) mice, the beneficial effect of CR as compared to the control diet was not observed based on the overall survival (Sirt2−/−; p53−/−: CR vs. ctrl p = 0.4 / Sirt2−/−; p53+/−: CR vs. ctrl p = 0.015) and the tumor incidence (Sirt2−/−; p53−/−: CR vs. ctrl p = 0.5/Sirt2−/−; p53+/−: CR vs. ctrl p = 0.1).