TP53 and neoplasm: This is reflected by increased overall survival (p53+/−: CR vs. ctrl p = 0.003 / p53−/−: CR vs. ctrl p = 0.03) and median survival (p53+/−: 446 days ctrl vs. 550 days CR/p53−/−: 179 days ctrl vs. 189 days CR), with concomitant significant decrease in tumor incidence (p53+/−: CR vs. ctrl p = 0.015-HR = 0.46/p53−/−: CR vs. ctrl p = 0.02-HR = 0.55, Figure 2 and Supplementary Table 1).