TP53 and neoplasm: In a p53 null background, Sirt3−/− mice fed a HFD did not show statistically significant decrease in survival (Sirt3−/−; p53−/−: HFD vs. ctrl p = 0.15) and tumor incidence (Sirt3−/−; p53−/−: HFD vs. ctrl p = 0.3) as compared to Sirt3+/+ mice (Figures 5A,B).