ANXA1 is a glucocorticoid-induced protein that is well-known to reproduce numerous anti-inflammatory effects of glucocorticoids and is implicated in the modulation of T-cell function and the adaptive immune response related to rheumatoid arthritis (146) and increasing data suggest that ANXA1, which act together with the formyl peptide receptor family, might have a major role in alleviating ischemia–reperfusion injury (136). This evidence concerns the gene ANXA1 and rheumatoid arthritis.