In fact, the expression level of ANXA1 is down-regulated in numerous types of cancer and is linked with metastasis, relapse, and poor prognosis (141, 143); ANXA1 is an endogenous inhibitor of NF-κB that may be stimulated in human cancer cells and in experimental mice models by powerful anti-inflammatory glucocorticoids and altered by non-steroidal anti-inflammatory drugs (143). This evidence concerns the gene NFKB1 and cancer.