ANXA1 and neoplasm: ANXA1 interacts with p53 to co-regulate Bid expression and stimulate cell death after OGD/R via the caspase-3 pathway (147) and it has been described that ANXA1 is one of the molecules that is involved in p53-mediated radio-response and the abnormal expression of ANXA1 in nasopharyngeal carcinoma NPC might affect the apoptosis of tumor cells caused by ionizing radiation decreasing radiotherapeutic efficacy (148).