ANXA1 interacts with p53 to co-regulate Bid expression and stimulate cell death after OGD/R via the caspase-3 pathway (147) and it has been described that ANXA1 is one of the molecules that is involved in p53-mediated radio-response and the abnormal expression of ANXA1 in nasopharyngeal carcinoma NPC might affect the apoptosis of tumor cells caused by ionizing radiation decreasing radiotherapeutic efficacy (148). This evidence concerns the gene TP53 and neoplasm.