Smooth curve and the result of generalized additive model showed that the relationship between LDH and in-hospital mortality was nonlinear after adjusting for age, gender, BMI, hypertension, diabetes, stroke, atherosclerosis, smoking, symptom, systolic blood pressure, diastolic blood pressure, type of AAD (Stanford), admission of white blood cell, hemoglobin, alanine transaminase, aspartate aminotransferase, albumin, creatinine, and management. The gene discussed is GPT; the disease is atherosclerosis.