Its inhibition decreases cell proliferation, induces G2/M cell cycle arrest, and produces synergistic effects with radiation in GBM cell lines.41 Another study showed that AURKA regulates self-renewal and tumorigenicity of GSCs by activating the Wnt signaling pathway.42 Other nodes of the cell cycle network include centromere proteins (CENPU, CENPO, and CENPQ). Here, AURKA is linked to glioblastoma.