Its inhibition decreases cell proliferation, induces G2/M cell cycle arrest, and produces synergistic effects with radiation in GBM cell lines.41 Another study showed that AURKA regulates self-renewal and tumorigenicity of GSCs by activating the Wnt signaling pathway.42 Other nodes of the cell cycle network include centromere proteins (CENPU, CENPO, and CENPQ). The gene discussed is CENPU; the disease is glioblastoma.