A recent analysis of a prospective Swiss cohort of 2023 patients hospitalized for acute coronary syndromes between 2009 and 2014 indicated that recommendations issued by the ACC guidelines would lead to 5-fold higher eligibility rates for PCSK9 inhibitors as compared to the ESC/EAS consensus statement at 1 year (13.4% vs. 2.7%, respectively) [30], simulating a fixed effect of ezetimibe. The gene discussed is PCSK9; the disease is acute coronary syndrome.