This is the first study to examine OS-related gene polymorphisms implicated in susceptibility of HBV-induced liver disease, clearance, and progression in the Han Chinese population, and found that CYBA-rs4673, NCF4-rs1883112, Nox4-rs1836882, and GCLM-rs41303970 are associated with HBV-induced liver disease. Here, CYBA is linked to liver disorder.