In this study, FA-97 (caffeic acid phenethyl ester 4-O-glucoside), a new synthetic caffeic acid phenethyl ester (CAPE) derivative is synthesized (Figure 1) and proved to ameliorate DSS-induced colitis against oxidative stress by activating Nrf2/HO-1 pathway in vivo and in vitro. The gene discussed is HMOX1; the disease is colitis.