The effect was observed both in macrophages pre-activated by IFN-γ and in those activated after the infection, even if in the latter case the intracellular signaling elicited by IFN-γ was probably prevented also because of the depletion of cholesterol from the lipid rafts, by the bacterial cholesterol-α-glucosyltransferase [Supplementary Figure 5; (46)]. The gene discussed is IFNG; the disease is infection.