Additionally, in the functional analysis, significant pathways associated with IL-17 were identified by IPA software, notably the “Differential regulation of cytokine production in macrophages by IL-17A and IL-17F” pathway, the “Differential regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17F” pathway, and the “Role of IL-17A in arthritis” pathway at 4 hpi (Supplementary Table 6) and during other MAP-infection periods (Supplementary Tables 5, 7, 8). The gene discussed is IL17F; the disease is infection.